Paget's disease of bone is a chronic skeletal disorder which may result in enlarged or deformed bones in one or more regions of the skeleton, due to abnormal increased renewal of bone, termed bone remodelling.
Bone remodelling is a process that is responsible for repair of damaged bone and mobilisation of minerals from bone to meet the body’s needs. Bone remodelling involves removal of bone from the skeleton (bone resorption) and its replacement with new bone (bone formation). This process is carried out in an orderly and balanced way to make sure that your bones stay strong and healthy.
In Paget’s disease of the bone, the normal regulation of bone remodelling is disrupted. The way that your bone is renewed and repaired has become abnormal.
These will quickly lead to the following problems:
- Bone starts to break down too quickly and in response, the process of making new bone speeds up.
- The renewal and repair of bone becomes chaotic and increases by up to 6-7 fold.
- The new bone isn’t made properly and is misshapen, weak and sometimes enlarged.